AI-10-49
AI-10-49 is a potent small molecule that selectively disrupts the interaction between the CBFβ-SMMHC oncoprotein and RUNX1, exhibiting an IC50 of 260 nM. This inhibitor is a valuable research tool for investigating acute myeloid leukemia (AML) pathogenesis and evaluating therapeutic strategies in cellular models.
Product Specifications
CAS Number
1256094-72-0
Product Name Alternative
Inhibit, Inhibitor, AI1049, AI-10-49, AI 10 49, DNASynthesis, DNA Synthesis, CBFβ-SMMHC, RNASynthesis, RNA Synthesis
Field of Research
Cell Biology, Molecular Biology
Purity
97.14% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5 mM) ; DMSO:93 mg/mL (140.8 mM) ; Ethanol:93 mg/mL (140.8 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
FC (F) (F) Oc1ccc2nc ([nH]c2c1) -c1ccc (OCCOCCOc2ccc (nc2) -c2nc3ccc (OC (F) (F) F) cc3[nH]2) cn1
Molecular Formula
C30H22F6N6O5
Molecular Weight
660.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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