AMG 925
AMG 925 is an orally active small molecule that potently inhibits both FLT3 and CDK4 kinases, exhibiting IC50 values of 1 nM and 3 nM, respectively. It is utilized in preclinical research for acute myeloid leukemia (AML), demonstrating antitumor efficacy in both cellular assays and animal models.
Product Specifications
CAS Number
1401033-86-0
Product Name Alternative
Inhibit, FLT3, Fms like tyrosine kinase 3, Inhibitor, AMG 925, AMG925, AMG-925, Cyclin dependent kinase, CDK, CDK1, CDK4, CD135, Cluster of differentiation antigen 135
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
99.42% (May vary between batches)
Solubility
DMSO:< 1 mg/mL (insoluble or slightly soluble)
Smiles
C[C@H]1CC[C@@H] (CC1) n1c2cnccc2c2cnc (Nc3ccc4CN (CCc4n3) C (=O) CO) nc12
Molecular Formula
C26H29N7O2
Molecular Weight
471.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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