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AMG319

AMG319 is a potent and selective PI3Kδ inhibitor (IC50 = 18 nM) with >47-fold selectivity against other PI3K isoforms. This compound has been utilized in Phase 2 clinical studies and preclinical research for investigating hematological malignancies and immune disorders in both cellular and animal models.

Product Specifications

CAS Number

1608125-21-8

Product Name Alternative

PI3K, PI3Kβ, PI3Kα, PI3Kγ, PI3Kδ, Phosphoinositide 3-kinase, Inhibitor, inhibit, AMG319, AMG-319, AMG 319

Field of Research

Signal Transduction

Purity

98.57% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.19 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:71 mg/mL (184.22 mM) ; Ethanol:71 mg/mL (184.22 mM)

Smiles

C[C@H] (Nc1ncnc2[nH]cnc12) c1cc2ccc (F) cc2nc1-c1ccccn1

Molecular Formula

C21H16FN7

Molecular Weight

385.4

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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