Xevinapant
Xevinapant (Debio-1143) is a potent small molecule Smac mimetic that antagonizes IAP proteins by binding with high affinity to XIAP and cIAP. It demonstrates pro-apoptotic activity in cancer research, showing efficacy in both in vitro cellular assays and in vivo preclinical tumor models.
Product Specifications
CAS Number
1071992-99-8
Product Name Alternative
Debio-1143, Debio 1143, Debio1143, IAP, Inhibitor, mimetic, oral, ovarian, inhibit, AT 406, AT406, AT-406, ARRY334543, ARRY-334543, ARRY 334543, cancer, cIAP2-BIR3, cIAP1-BIR3, degradation, XIAP-BIR3, Xevinapant, Smac, SM406, SM-406, SM 406
Field of Research
Cell Biology
Purity
98.00% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.56 mM) ; Ethanol:93 mg/mL (165.57 mM) ; DMSO:127.75 mg/mL (227.43 mM)
Smiles
CN[C@@H] (C) C (=O) N[C@H]1CN (CC[C@H]2CC[C@H] (N2C1=O) C (=O) NC (c1ccccc1) c1ccccc1) C (=O) CC (C) C
Molecular Formula
C32H43N5O4
Molecular Weight
561.71
Storage Conditions
-20°C
Notes
For research use only.
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