AZ6102
AZ6102 is a highly selective small molecule inhibitor of TNKS1 and TNKS2, demonstrating potent inhibition of the Wnt signaling pathway with an IC50 of 5 nM in DLD-1 cells. It exhibits >100-fold selectivity over other PARP family members, making it a valuable chemical probe for studying Wnt-driven cancers in both cellular and animal models.
Product Specifications
CAS Number
1645286-75-4
Product Name Alternative
Betacatenin, beta-catenin, AZ 6102, AZ6102, AZ-6102, bcatenin, PARP, inhibit, Inhibitor, Wnt/betacatenin, Wnt, Wnt/b-catenin, Wnt/β-catenin, poly ADP ribose polymerase, TNKS1, TNKS2, βcatenin
Field of Research
Epigenetics & Chromatin, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.98% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.67 mM) ; DMSO:21.4 mg/mL (49.94 mM)
Smiles
C[C@H]1CN (C[C@@H] (C) N1) c1cc (C) c (cn1) -c1ccc (cc1) -c1nc2n (C) ccc2c (=O) [nH]1
Molecular Formula
C25H28N6O
Molecular Weight
428.53
Storage Conditions
-20°C
Notes
For research use only.
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