AZD8186
AZD8186 is a potent and selective small molecule inhibitor of PI3Kβ and PI3Kδ isoforms, with IC50 values of 4 nM and 12 nM, respectively. It is a valuable research tool for studying PI3K signaling in oncology, particularly in PTEN-deficient cancers, and has been utilized in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
1627494-13-6
Product Name Alternative
Inhibit, Inhibitor, AZD 8186, AZD8186, AZD-8186, Phosphoinositide 3-kinase, PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, PI3K
Field of Research
Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
Ethanol:3 mg/mL (6.56 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.21 mM) ; DMSO:84 mg/mL (183.62 mM)
Smiles
C[C@@H] (Nc1cc (F) cc (F) c1) c1cc (cc2c1oc (cc2=O) N1CCOCC1) C (=O) N (C) C
Molecular Formula
C24H25F2N3O4
Molecular Weight
457.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
32-7010-10 10 µg
Recombinant Human CD40 Ligand/CD40L/TNFSF5 (E. coli)
Sign In for Pricing
View Details R1402m 1 Each
Mouse Ptpn1 / Tyrosine-protein phosphatase non-receptor type 1 Recombinant Protein
Sign In for Pricing
View Details 
47890121 3x 1.0µg DNA
TRNAA21 CRISPRa sgRNA lentivector (set of three targets)(Human)
Sign In for Pricing
View Details