BMS-911543
BMS-911543 is a highly selective JAK2 inhibitor (IC50 = 1.1 nM) with significant selectivity over JAK1, JAK3, and TYK2. It is a valuable research tool for investigating JAK2-dependent pathways in myeloproliferative neoplasms and hematological malignancies, as evidenced in both in vitro and in vivo preclinical studies.
Product Specifications
CAS Number
1271022-90-2
Product Name Alternative
SET-2, Tyrosine Kinases, TyrosineKinases, TYK2, BMS 911543, BMS911543, BMS-911543, Inhibitor, HistoneMethyltransferase, Histone Methyltransferase, JAK3, Janus kinase, JAK2, JAK, JAK1, inhibit
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.69% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.62 mM) ; DMSO:34 mg/mL (78.61 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:21 mg/mL (48.55 mM)
Smiles
CCn1c (cc2c1nc (Nc1cc (C) n (C) n1) c1ncn (C) c21) C (=O) N (C1CC1) C1CC1
Molecular Formula
C23H28N8O
Molecular Weight
432.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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