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CB-5083

CB-5083 is a potent, selective, and orally available inhibitor of the p97 AAA ATPase, with an IC50 of 11 nM. It is widely used in cancer research to study protein homeostasis and has demonstrated antitumor activity in both cellular assays and in vivo xenograft models.

Product Specifications

CAS Number

1542705-92-9

Product Name Alternative

Cdc48, CB5083, CB-5083, CB 5083, ATPase, AAA, p97, Inhibitor, inhibit, multiple, myeloma, VCP, tumors, solid

Field of Research

Protein Biochemistry

Purity

95.95% (May vary between batches)

Solubility

H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:11 mg/mL (26.6 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:6 mg/mL (14.51 mM) ; DMSO:247.5 mg/mL (598.59 mM)

Smiles

Cc1cc2c (cccc2n1-c1nc2CCOCc2c (NCc2ccccc2) n1) C (N) =O

Molecular Formula

C24H23N5O2

Molecular Weight

413.47

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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