CB-5083
CB-5083 is a potent, selective, and orally available inhibitor of the p97 AAA ATPase, with an IC50 of 11 nM. It is widely used in cancer research to study protein homeostasis and has demonstrated antitumor activity in both cellular assays and in vivo xenograft models.
Product Specifications
CAS Number
1542705-92-9
Product Name Alternative
Cdc48, CB5083, CB-5083, CB 5083, ATPase, AAA, p97, Inhibitor, inhibit, multiple, myeloma, VCP, tumors, solid
Field of Research
Protein Biochemistry
Purity
95.95% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:11 mg/mL (26.6 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:6 mg/mL (14.51 mM) ; DMSO:247.5 mg/mL (598.59 mM)
Smiles
Cc1cc2c (cccc2n1-c1nc2CCOCc2c (NCc2ccccc2) n1) C (N) =O
Molecular Formula
C24H23N5O2
Molecular Weight
413.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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