FIIN-2
FIIN-2 is an irreversible pan-FGFR inhibitor exhibiting potent activity against FGFR1-4 with IC50 values of 3.09, 4.3, 27, and 45.3 nM, respectively. It is a valuable chemical probe for studying FGFR-driven pathologies in both cellular assays and preclinical cancer models.
Product Specifications
CAS Number
1633044-56-0
Product Name Alternative
Inhibitor, Fibroblast growth factor receptor, FGFR2, FGFR, FGFR1, FGFR4, FGFR3, FIIN 2, FIIN2, FIIN-2, inhibit
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.82% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:64 mg/mL (100.83 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.15 mM)
Smiles
COc1cc (OC) cc (c1) N1Cc2cnc (Nc3ccc (cc3) N3CCN (C) CC3) nc2N (Cc2ccc (NC (=O) C=C) cc2) C1=O
Molecular Formula
C35H38N8O4
Molecular Weight
634.73
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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