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FIIN-2

FIIN-2 is an irreversible pan-FGFR inhibitor exhibiting potent activity against FGFR1-4 with IC50 values of 3.09, 4.3, 27, and 45.3 nM, respectively. It is a valuable chemical probe for studying FGFR-driven pathologies in both cellular assays and preclinical cancer models.

Product Specifications

CAS Number

1633044-56-0

Product Name Alternative

Inhibitor, Fibroblast growth factor receptor, FGFR2, FGFR, FGFR1, FGFR4, FGFR3, FIIN 2, FIIN2, FIIN-2, inhibit

Field of Research

Cardiovascular Research, Signal Transduction

Purity

97.82% (May vary between batches)

Solubility

H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:64 mg/mL (100.83 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.15 mM)

Smiles

COc1cc (OC) cc (c1) N1Cc2cnc (Nc3ccc (cc3) N3CCN (C) CC3) nc2N (Cc2ccc (NC (=O) C=C) cc2) C1=O

Molecular Formula

C35H38N8O4

Molecular Weight

634.73

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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