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G007-LK

G007-LK is a potent and selective dual inhibitor of tankyrase 1 (TNKS1) and tankyrase 2 (TNKS2), exhibiting IC50 values of 46 nM and 25 nM, respectively. This small molecule is a valuable chemical probe for studying Wnt/β-catenin signaling in cancer research and has been utilized in both cellular and in vivo models to investigate tankyrase function.

Product Specifications

CAS Number

1380672-07-0

Product Name Alternative

Inhibitor, G007 LK, G007LK, G-007-LK, G007-LK, inhibit, PARP, bcatenin, beta-catenin, betacatenin, Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, poly ADP ribose polymerase, TNKS1, TNKS2, βcatenin

Field of Research

Epigenetics & Chromatin, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Purity

97.63% (May vary between batches)

Solubility

10% DMSO+90% Corn Oil:3.3 mg/mL (6.23 mM) ; DMSO:93 mg/mL (175.48 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Smiles

CS (=O) (=O) c1ccc (nc1) -c1nnc (\C=C\c2nnc (o2) -c2ccc (cc2) C#N) n1-c1ccccc1Cl

Molecular Formula

C25H16ClN7O3S

Molecular Weight

529.96

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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