GSK591
GSK591 (EPZ015866) is a potent and selective PRMT5 inhibitor with an IC50 of 11 nM. It is a valuable chemical probe for investigating PRMT5 biology in cancer research, demonstrating utility in both in vitro cellular assays and in vivo preclinical models of hematologic malignancies.
Product Specifications
CAS Number
1616391-87-7
Product Name Alternative
HistoneMethyltransferase, Histone Methyltransferase, Inhibitor, GSK591, GSK-591, GSK 591, GSK 3203591, GSK3203591, GSK-3203591, EPZ015866, EPZ-015866, EPZ 015866, inhibit, PRMT5
Field of Research
Epigenetics & Chromatin
Purity
99.09% (May vary between batches)
Solubility
DMSO:60 mg/mL (157.7 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM)
Smiles
O[C@@H] (CNC (=O) c1ccnc (NC2CCC2) c1) CN1CCc2ccccc2C1
Molecular Formula
C22H28N4O2
Molecular Weight
380.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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