Halofuginone
Halofuginone is a potent, competitive inhibitor of prolyl-tRNA synthetase (Ki=18.3 nM) that downregulates Smad3 and blocks TGF-β signaling at low nanomolar concentrations. This small molecule is a valuable research tool for studying fibrotic diseases, cancer biology, and T-cell differentiation in both cellular and animal models.
Product Specifications
CAS Number
55837-20-2
Product Name Alternative
DNA Synthesis, DNA/RNA Synthesis, DNASynthesis, collagen, collagen-1, CalciumChannel, Calcium Channel, osteoarthritis, Parasite, Halofuginone, prolyl-tRNA, prolyl-tRNA synthetase, RU 19110, RU19110, RU-19110, RNASynthesis, RNA Synthesis, Sodium Channel, SodiumChannel, Smad, Tempostatin, TGFb, TGF-β, TGF-β/Smad, TGFbeta, TGF-b/Smad, TGF-beta, TGFbeta/Smad, TGF-beta/Smad, TGFβ, Transforming growth factor beta, type-I
Field of Research
Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
95.35% (May vary between batches)
Solubility
DMSO:4.15 mg/mL (10.01 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.41 mM)
Smiles
O[C@@H]1CCCN[C@H]1CC (=O) Cn1cnc2cc (Br) c (Cl) cc2c1=O
Molecular Formula
C16H17BrClN3O3
Molecular Weight
414.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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