LY3009120
LY3009120 is a potent pan-Raf inhibitor, demonstrating IC50 values of 44 nM, 31-47 nM, and 42 nM against A-Raf, B-Raf, and C-Raf, respectively, in A375 cell assays. This investigational compound has been evaluated in Phase 1 clinical trials for its potential in oncology research, supporting studies into MAPK pathway signaling in both cellular and in vivo models.
Product Specifications
CAS Number
1454682-72-4
Product Name Alternative
DP 4978, DP4978, DP-4978, C-Raf, B-Raf (V600E), B-Raf (WT), Autophagy, LY 3009120, LY3009120, LY-3009120, inhibit, Inhibitor, Raf kinases, Raf
Field of Research
Cell Biology, Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
DMSO:10 mg/mL (23.56 mM)
Smiles
CNc1ncc2cc (c (C) nc2n1) -c1cc (NC (=O) NCCC (C) (C) C) c (F) cc1C
Molecular Formula
C23H29FN6O
Molecular Weight
424.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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