MCC950
MCC950 sodium is a highly potent and selective NLRP3 inflammasome inhibitor, with IC50 values of 7.5 nM and 8.1 nM in mouse and human macrophages, respectively. It shows no activity against AIM2, NLRC4, or NLRP1 inflammasomes. This compound is widely used in research to investigate NLRP3-driven pathologies in both cellular and animal models of inflammatory diseases.
Product Specifications
CAS Number
256373-96-3
Product Name Alternative
CRID3; CP-456773 sodium salt
Field of Research
Cell Biology, Immunology & Inflammation, Neuroscience
Purity
>98%
Bioactivity
NLRP3 inflammasome inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 40 mg/ml) or in Water (up to 30 mg/ml) .
Smiles
[Na+].CC (C) (O) c1coc (c1) S (=O) (=O) [N-]C (=O) Nc1c2CCCc2cc2CCCc12
Molecular Formula
C20H23N2O5S • Na
Molecular Weight
426.46
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N-[[ (1,2,3,5,6,7-Hexahydro-s-indacen-4-yl) amino]carbonyl]-4- (1-hydroxy-1-methylethyl) -2-furansulfonamide sodium salt
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