Monomethyl auristatin E
Monomethyl auristatin E (MMAE) is a potent tubulin polymerization inhibitor that disrupts cell division. It serves as the cytotoxic payload in numerous antibody-drug conjugates (ADCs) and is widely used in oncology research for both in vitro cytotoxicity studies and in vivo xenograft models.
Product Specifications
CAS Number
474645-27-7
Product Name Alternative
Microtubule Associated, microtubule, MicrotubuleAssociated, Microtubule/Tubulin, MMAE, inhibit, Inhibitor, Monomethyl auristatin E, ADCCytotoxin, ADC Cytotoxin, ADC Payload, Apoptosis, SGD 1010, SGD1010, SGD-1010, Vedotin
Field of Research
Cell Biology, Signal Transduction
Purity
98.47% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.79 mM) ; DMSO:71.8 mg/mL (100 mM)
Smiles
CC[C@H] (C) C ([C@@H] (CC (=O) N1CCC[C@H]1C (OC) [C@@H] (C) C (=O) N[C@H] (C) [C@@H] (O) c1ccccc1) OC) N (C) [C@@H] (C (C) C) C (=O) NC (=O) [C@@H] (NC) C (C) C
Molecular Formula
C39H67N5O7
Molecular Weight
717.98
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
