Monomethyl auristatin E
Monomethyl auristatin E (MMAE) is a potent tubulin polymerization inhibitor that disrupts cell division. It serves as the cytotoxic payload in numerous antibody-drug conjugates (ADCs) and is widely used in oncology research for both in vitro cytotoxicity studies and in vivo xenograft models.
Product Specifications
CAS Number
474645-27-7
Product Name Alternative
Microtubule Associated, microtubule, MicrotubuleAssociated, Microtubule/Tubulin, MMAE, inhibit, Inhibitor, Monomethyl auristatin E, ADCCytotoxin, ADC Cytotoxin, ADC Payload, Apoptosis, SGD 1010, SGD1010, SGD-1010, Vedotin
Field of Research
Cell Biology, Signal Transduction
Purity
98.47% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.79 mM) ; DMSO:71.8 mg/mL (100 mM)
Smiles
CC[C@H] (C) C ([C@@H] (CC (=O) N1CCC[C@H]1C (OC) [C@@H] (C) C (=O) N[C@H] (C) [C@@H] (O) c1ccccc1) OC) N (C) [C@@H] (C (C) C) C (=O) NC (=O) [C@@H] (NC) C (C) C
Molecular Formula
C39H67N5O7
Molecular Weight
717.98
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K2184703 1.0 µg DNA
SLC32A1 sgRNA CRISPR Lentivector (Human) (Target 2)
Sign In for Pricing
View Details 
K4018004 1.0 µg DNA
Btla sgRNA CRISPR Lentivector (Mouse) (Target 3)
Sign In for Pricing
View Details