Necrosulfonamide
Necrosulfonamide is a selective small molecule inhibitor of MLKL that blocks necroptosis by disrupting the MLKL-RIP1-RIP3 complex. It is widely used in both in vitro and in vivo research to investigate programmed necrosis in contexts like inflammatory disease and ischemia-reperfusion injury.
Product Specifications
CAS Number
1360614-48-7
Product Name Alternative
Complex, (E) -Necrosulfonamide, Mixed Lineage Kinase, necrosis (MLKL), necrosome, necrosis, Necrosulfonamide, MLKs, inhibit, formation, Inhibitor, substrate, RIP3
Field of Research
Cell Biology, Neuroscience
Purity
>98%
Bioactivity
Pyroptosis / necroptosis inhibitor; MLKL pseudokinase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 10 mg/ml)
Smiles
COc1nccnc1NS (=O) (=O) c1ccc (NC (=O) \C=C\c2ccc (s2) [N+] ([O-]) =O) cc1
Molecular Formula
C18H15N5O6S2
Molecular Weight
461.47
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(2E) -N-[4-[[ (3-Methoxy-2-pyrazinyl) amino]sulfonyl]phenyl]-3- (5-nitro-2-thienyl) -2-propenamide
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