NSC-87877 disodium
NSC-87877 is a dual SHP-1 and SHP-2 inhibitor (IC50 ~355 and 318 nM) that suppresses EGF-stimulated Erk1/2 activation in vitro. It demonstrates anti-proliferative effects in breast cancer cell lines and has been utilized in research exploring oncogenic signaling and immune regulation.
Product Specifications
CAS Number
56932-43-5
Product Name Alternative
Apoptosis, HSP27, Inhibitor, NSC87877, NSC-87877, NSC87877 disodium, NSC-87877 disodium, Neuroblastoma, p53, inhibit, NSC 87877, NSC 87877 disodium, PPAR, p38, SHP-2, SHP-1, Phosphatase
Field of Research
Cell Biology, Metabolism Research, Neuroscience
Purity
97.89% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:92 mg/mL (182.75 mM) ; DMSO:93 mg/mL (184.74 mM)
Smiles
[Na+].[Na+].Oc1c (cc (c2cccnc12) S ([O-]) (=O) =O) \N=N\c1ccc2cc (ccc2c1) S ([O-]) (=O) =O
Molecular Formula
C19H13N3O7S2·2Na
Molecular Weight
503.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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