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Pamapimod

Pamapimod (R1503) is a selective p38 MAPK inhibitor, targeting the p38α and p38β isoforms with IC50 values of 14 nM and 480 nM, respectively. It has been utilized in preclinical research to investigate p38's role in inflammatory diseases, with studies demonstrating its effects in both cellular assays and animal models of arthritis.

Product Specifications

CAS Number

449811-01-2

Product Name Alternative

Autophagy, anti-inflammation, inhibit, IL-1β, IL-6, Inhibitor, JNK, Pamapimod, LPS, p38 MAPK, p38MAPK, p38α, p38β, R 1503, R1503, R-1503, TNF-α, Ro4402257, Ro-4402257, Ro 4402257

Field of Research

Cell Biology, Signal Transduction

Purity

97.63% (May vary between batches)

Solubility

DMSO:45 mg/mL (110.73 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:27 mg/mL (66.44 mM)

Smiles

Cn1c2nc (NC (CCO) CCO) ncc2cc (Oc2ccc (F) cc2F) c1=O

Molecular Formula

C19H20F2N4O4

Molecular Weight

406.38

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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