Pamapimod
Pamapimod (R1503) is a selective p38 MAPK inhibitor, targeting the p38α and p38β isoforms with IC50 values of 14 nM and 480 nM, respectively. It has been utilized in preclinical research to investigate p38's role in inflammatory diseases, with studies demonstrating its effects in both cellular assays and animal models of arthritis.
Product Specifications
CAS Number
449811-01-2
Product Name Alternative
Autophagy, anti-inflammation, inhibit, IL-1β, IL-6, Inhibitor, JNK, Pamapimod, LPS, p38 MAPK, p38MAPK, p38α, p38β, R 1503, R1503, R-1503, TNF-α, Ro4402257, Ro-4402257, Ro 4402257
Field of Research
Cell Biology, Signal Transduction
Purity
97.63% (May vary between batches)
Solubility
DMSO:45 mg/mL (110.73 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:27 mg/mL (66.44 mM)
Smiles
Cn1c2nc (NC (CCO) CCO) ncc2cc (Oc2ccc (F) cc2F) c1=O
Molecular Formula
C19H20F2N4O4
Molecular Weight
406.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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