PD168393
PD168393 is a potent and irreversible EGFR inhibitor (IC50: 0.70 nM) that selectively targets Cys-773. It demonstrates high selectivity, showing no activity against PKC, FGFR, PDGFR, or insulin receptor. This compound is widely used in vitro and in vivo to study EGFR-driven oncogenic signaling and tumor growth.
Product Specifications
CAS Number
194423-15-9
Product Name Alternative
IGF1R, Inhibitor, Insulin Receptor, HER1, Epidermal growth factor receptor, epidermoid carcinoma, ErbB-1, EGFR, FGFR, inhibit, PDGFR, PD168393, PD-168393, PD 168393, Autophagy, Apoptosis, PKC, tumor
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction
Purity
99.04% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.42 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:40 mg/mL (108.34 mM)
Smiles
Brc1cccc (Nc2ncnc3ccc (NC (=O) C=C) cc23) c1
Molecular Formula
C17H13BrN4O
Molecular Weight
369.22
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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