PFI-3
PFI-3 is a potent and selective chemical probe targeting the bromodomains of SMARCA2/4 and PB1 proteins with a Kd of 89 nM. It is widely used in vitro and in vivo to investigate epigenetic mechanisms in oncology, particularly for studying potential therapeutic strategies in breast cancer models.
Product Specifications
CAS Number
1819363-80-8
Product Name Alternative
PB1 (5) bromodomains, inhibit, Inhibitor, Epigenetic Reader Domain, EpigeneticReaderDomain, SMARCA2, SMARCA4, PFI 3, PFI3, PFI-3
Field of Research
Epigenetics & Chromatin, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Bromodomain inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to at least 25 mg/ml)
Smiles
[H][C@@]12CN (c3ccccn3) [C@@] ([H]) (CN1\C=C\C (=O) c1ccccc1O) C2
Molecular Formula
C19H19N3O2
Molecular Weight
321.4
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(2E) -1- (2-Hydroxyphenyl) -3-[ (1R,4R) -5- (pyridine-2-yl) -2,5-diazabicyclo{2.2.1]heptan-2-yl]prop-2-en-1-one
Available Sizes
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