Picropodophyllotoxin
Picropodophyllin (PPP) is a potent and selective IGF-1R inhibitor with an IC50 of 1 nM. It downregulates IGF1R expression without affecting related receptors like InsR. This specificity makes it a valuable research tool for studying IGF-1R signaling in cancer models, both in vitro and in vivo.
Product Specifications
CAS Number
477-47-4
Product Name Alternative
AXL 1717, AXL1717, AXL-1717, Apoptosis, IGF-1R, IGF1R, Picropodophyllin, Picropodophyllin (PPP), Picropodophyllotoxin, PPP
Field of Research
Cardiovascular Research
Purity
>98%
Bioactivity
IGF1R inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 40 mg/ml) .
Smiles
[H][C@]12COC (=O) [C@@]1 ([H]) [C@H] (c1cc (OC) c (OC) c (OC) c1) c1cc3OCOc3cc1[C@@H]2O
Molecular Formula
C22 H22 O8
Molecular Weight
414.42
Storage Conditions
RT
Notes
For research use only.
Other Product Names
(5R,5aS,8aR,9R) -5,8,8a,9-Tetrahydro¬-9-hydroxy-5- (3,4,5-trimethoxyphenyl) -furo[3',4':6,7¬]naphtho[2,3-d]-1,3-dioxol-6 (5aH) -one
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
