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PNU-120596

PNU-120596 (NSC-216666) is a potent and selective positive allosteric modulator of the α7 nicotinic acetylcholine receptor, exhibiting an EC50 of 216 nM. It is widely used in neuroscience research to potentiate α7 nAChR currents and has been employed in both in vitro and in vivo studies investigating cognitive function and neuropsychiatric disorders.

Product Specifications

CAS Number

501925-31-1

Product Name Alternative

IL-6, Inhibitor, inhibit, inflammatory, pain, NSC216666, NSC-216666, NSC 216666, nAChR, PNU 120596, PNU120596, PNU-120596, Nicotinic acetylcholine receptors, neurological, anti-hyperalgesia, disorders, α7nAChR, α7 nAChR, TNF-α

Field of Research

Neuroscience

Purity

98.34% (May vary between batches)

Solubility

DMSO:31.2 mg/mL (100.09 mM) ;10% DMSO+90% Corn Oil:2 mg/mL (6.42 mM)

Smiles

COc1cc (OC) c (NC (=O) Nc2cc (C) on2) cc1Cl

Molecular Formula

C13H14ClN3O4

Molecular Weight

311.72

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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