PNU-120596
PNU-120596 (NSC-216666) is a potent and selective positive allosteric modulator of the α7 nicotinic acetylcholine receptor, exhibiting an EC50 of 216 nM. It is widely used in neuroscience research to potentiate α7 nAChR currents and has been employed in both in vitro and in vivo studies investigating cognitive function and neuropsychiatric disorders.
Product Specifications
CAS Number
501925-31-1
Product Name Alternative
IL-6, Inhibitor, inhibit, inflammatory, pain, NSC216666, NSC-216666, NSC 216666, nAChR, PNU 120596, PNU120596, PNU-120596, Nicotinic acetylcholine receptors, neurological, anti-hyperalgesia, disorders, α7nAChR, α7 nAChR, TNF-α
Field of Research
Neuroscience
Purity
98.34% (May vary between batches)
Solubility
DMSO:31.2 mg/mL (100.09 mM) ;10% DMSO+90% Corn Oil:2 mg/mL (6.42 mM)
Smiles
COc1cc (OC) c (NC (=O) Nc2cc (C) on2) cc1Cl
Molecular Formula
C13H14ClN3O4
Molecular Weight
311.72
Storage Conditions
-20°C
Notes
For research use only.
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