RG7112
RG7112 (RO5045337) is an orally available, selective small molecule inhibitor of the MDM2-p53 interaction. It is used in cancer research to reactivate wild-type p53 function, demonstrating antitumor activity in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
939981-39-2
Product Name Alternative
Inhibitor, inhibit, Mdm2, MDM-2/p53, E3 ligating enzyme, E1 Enzyme, E1/E2/E3 Enzyme, E2 conjugating enzyme, E1Enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, E3Enzyme, E1 activating enzyme, RG7112, RG-7112, RG 7112, RO 5045337, RO5045337, RO-5045337, Ubiquitin ligase, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme
Field of Research
Cell Biology, Protein Biochemistry
Purity
99.17% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:93 mg/mL (127.79 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (13.74 mM) ; Ethanol:93 mg/mL (127.79 mM)
Smiles
CCOc1cc (ccc1C1=NC (C) (c2ccc (Cl) cc2) C (C) (N1C (=O) N1CCN (CCCS (C) (=O) =O) CC1) c1ccc (Cl) cc1) C (C) (C) C
Molecular Formula
C38H48Cl2N4O4S
Molecular Weight
727.78
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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