Ro 5126766
RO5126766 (CH5126766) is a dual RAF/MEK inhibitor currently in Phase 1 clinical development. It potently inhibits BRAF V600E, BRAF, CRAF, and MEK1 with IC50 values ranging from 8.2 nM to 160 nM. This compound is a valuable research tool for investigating the MAPK pathway in both in vitro and in vivo cancer models.
Product Specifications
CAS Number
946128-88-7
Product Name Alternative
Inhibit, Mitogen-activated protein kinase kinase, MAP2K, MAPKK, MEK1, MEK, Inhibitor, C-Raf, CH5126766, CH-5126766, CH 5126766, Avutometinib, B-Raf (V600E), B-Raf, RO5126766, RO-5126766, Ro-5126766, Ro 5126766, Raf kinases, Raf, VS-6766
Field of Research
Signal Transduction
Purity
98.13% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (10.61 mM) ; DMSO:87 mg/mL (184.53 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CNS (=O) (=O) Nc1nccc (Cc2c (C) c3ccc (Oc4ncccn4) cc3oc2=O) c1F
Molecular Formula
C21H18FN5O5S
Molecular Weight
471.46
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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