RS-127445

RS-127445 (MT500) is a potent and highly selective 5-HT2B receptor antagonist, with a pKi of 9.5 and a pIC50 of 10.4, demonstrating over 1000-fold selectivity versus other serotonin receptors. This tool compound is widely used in cardiovascular and fibrotic disease research, facilitating both in vitro binding assays and in vivo pharmacological studies.

Product Specifications

CAS Number

199864-87-4

Product Name Alternative

5-HT2B, 5HT Receptor, 5-HT Receptor, 5-hydroxytryptamine Receptor, 5HTReceptor, inhibit, MT 500, MT500, MT-500, Inhibitor, Serotonin Receptor, RS 127445, RS127445, RS-127445

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Purity

98.81% (May vary between batches)

Solubility

Ethanol:8 mg/mL (28.44 mM) ; DMSO:52 mg/mL (184.84 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.55 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)