ARN-21934

ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etoposide (IC50=120 μM) . ARN-21934 exhibits a favorable in vivo pharmacokinetic profile and is a promising lead compound for anticancer research[1].

Product Specifications

CAS Number

[2230854-93-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/arn-21934.html

Purity

98.08

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

NC1CC2=C(NC3=CC=C(N(C)C)C=C3)N=C(C4=CC=NC=C4)N=C2CC1

Molecular Formula

C21H24N6

Molecular Weight

360.46

Precautions

H302, H315, H319

References & Citations

[1]Jose Antonio Ortega, et al. Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β. J Med Chem. 2020 Nov 12;63 (21) :12873-12886.