PNU 74654
PNU 74654 is a small molecule inhibitor that disrupts Wnt/β-catenin signaling by binding β-catenin (Kd = 450 nM) and blocking its interaction with Tcf4. This tool compound is used in vitro and in vivo to study oncogenesis and stem cell biology driven by aberrant Wnt pathway activation.
Product Specifications
CAS Number
113906-27-7
Product Name Alternative
Bcatenin, Apoptosis, Beta catenin, betacatenin, beta-catenin, inhibit, Inhibitor, Wnt/betacatenin, Wnt/b-catenin, Wnt, Wnt/β-catenin, PNU 74654, PNU74654, PNU-74654, β-catenin, βcatenin
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Wnt pathway inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) .
Smiles
Cc1ccc (\C=N\NC (=O) c2ccccc2Oc2ccccc2) o1
Molecular Formula
C19H16N2O3
Molecular Weight
320.35
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-Phenoxybenzoic acid [ (5-methyl-2-furanyl) methylene]hydrazide
Available Sizes
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