THZ2
THZ2 (CDK7-IN-1) is a potent and selective CDK7 inhibitor derived from THZ1, exhibiting an IC50 of 13.9 nM. It is a research tool for investigating CDK7's role in transcription and cell cycle progression, with studies demonstrating its potential efficacy in models of triple-negative breast cancer (TNBC) both in vitro and in vivo.
Product Specifications
CAS Number
1604810-84-5
Product Name Alternative
Inhibitor, inhibit, Cyclin dependent kinase, CDK7-IN-1, CDK, THZ2, THZ-2, THZ 2
Field of Research
Cell Biology
Purity
98.00% (May vary between batches)
Solubility
DMSO:39 mg/mL (68.9 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.53 mM)
Smiles
CN (C) C\C=C\C (=O) Nc1cccc (c1) C (=O) Nc1cccc (Nc2ncc (Cl) c (n2) -c2c[nH]c3ccccc23) c1
Molecular Formula
C31H28ClN7O2
Molecular Weight
566.05
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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