CU-CPT9b
CU-CPT9b is a potent and selective TLR8 antagonist with a Kd of 21 nM. It inhibits R-848-induced NF-κB activation in TLR8-overexpressing HEK-Blue cells with an IC50 of 0.7 nM. This tool compound is valuable for in vitro studies investigating TLR8 signaling and its role in autoimmune, inflammatory, and antiviral research.
Product Specifications
CAS Number
2162962-69-6
Product Name Alternative
CUCPT9b, CU-CPT9b, CU-CPT-9b, CU CPT9b, Inhibitor, inhibit, TLR8-specific antagonist 1, TLR8, TLR, Toll-like Receptor (TLR)
Field of Research
Immunology & Inflammation
Purity
98.00% (May vary between batches)
Solubility
DMSO:100 mg/mL (397.96 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.92 mM)
Smiles
Cc1cc (ccc1O) -c1ccnc2cc (O) ccc12
Molecular Formula
C16H13NO2
Molecular Weight
251.28
Storage Conditions
-20°C
Notes
For research use only.
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