Theliatinib
Theliatinib is a potent and highly selective EGFR inhibitor, exhibiting a Ki of 0.05 nM for wild-type EGFR. It demonstrates anti-tumor activity in research models, with IC50 values of 3 nM and 22 nM against EGFR and the EGFR T790M/L858R mutant, respectively. This compound is applied in preclinical oncology research for investigating EGFR-driven cancers both in vitro and in vivo.
Product Specifications
CAS Number
1353644-70-8
Product Name Alternative
HMPL309, HMPL-309, HMPL 309, Inhibitor, HER1, ERK, esophageal, ErbB-1, Epidermal growth factor receptor, EGFR, inhibit, orally, anti-tumor, ATP-competitive, cancer, AKT, Theliatinib, Xiliertinib, phosphorylation
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
DMSO:47 mg/mL (106.21 mM)
Smiles
[H][C@]12CCN (C) [C@@]1 ([H]) CN (C2) C (=O) Nc1cc2c (Nc3cccc (c3) C#C) ncnc2cc1OC
Molecular Formula
C25H26N6O2
Molecular Weight
442.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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