LF3
LF3 is a potent small molecule inhibitor that selectively disrupts the β-catenin/TCF4 interaction, a key node in canonical Wnt signaling, with an IC50 below 2 μM. It is a valuable research tool for investigating Wnt pathway biology in both cellular assays and in vivo disease models, including cancer and stem cell research.
Product Specifications
CAS Number
664969-54-4
Product Name Alternative
Wnt/β-catenin, Wnt, Wnt/b-catenin, Wnt/betacatenin, β-catenin, βcatenin, beta-catenin, betacatenin, Beta catenin, bcatenin, Inhibitor, LF3, LF-3, LF 3, inhibit
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
≥95% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.8 mM) ; DMSO:32 mg/mL (76.82 mM)
Smiles
NS (=O) (=O) c1ccc (NC (=S) N2CCN (C\C=C\c3ccccc3) CC2) cc1
Molecular Formula
C20H24N4O2S2
Molecular Weight
416.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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