ARS-853
ARS-853 is a small molecule inhibitor targeting the oncogenic mutant K-RASG12C (IC50: 2.5 μM) . It covalently binds to the GDP-bound form, trapping it in an inactive state to inhibit proliferation in cancer cell lines. This tool compound is used in vitro to study RAS-driven tumor biology and signaling pathways.
Product Specifications
CAS Number
1629268-00-3
Product Name Alternative
Apoptosis, ARS 853, ARS853, ARS-853, cancer, inhibit, KRAS, K-Ras (G12C), mutant, inactive, G12C, Inhibitor, state, Ras, selective, covalent
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
96.64% (May vary between batches)
Solubility
DMSO:5.5 mg/mL (12.7 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.31 mM)
Smiles
CC1 (CC1) c1cc (NCC (=O) N2CCN (CC2) C2CN (C2) C (=O) C=C) c (O) cc1Cl
Molecular Formula
C22H29ClN4O3
Molecular Weight
432.94
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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