Selitrectinib
Selitrectinib (LOXO-195) is a highly potent and selective next-generation TRK inhibitor, targeting TrkA and TrkC with IC50 values of 0.6 and <2.5 nM, respectively. It is a valuable research tool for studying TRK-driven cancers, demonstrating activity in both cellular assays and in vivo models of acquired resistance to first-generation TRK inhibitors.
Product Specifications
CAS Number
2097002-61-2
Product Name Alternative
Inhibitor, inhibit, LOXO195, LOXO-195, LOXO 195, Selitrectinib, Trk Receptor, Trkreceptor, Trk receptor, Trk, Tropomyosin related kinase receptor
Field of Research
Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM) ; DMSO:65 mg/mL (170.86 mM)
Smiles
[H][C@]12CCCN1c1ccn3ncc (C (=O) N[C@H] (C) CCc4ncc (F) cc24) c3n1
Molecular Formula
C20H21FN6O
Molecular Weight
380.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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