TIC10
TIC-10 (ONC-201) is a clinical-stage small molecule that induces TRAIL expression via Foxo3a activation following Akt/ERK inhibition. Its favorable drug-like properties, including blood-brain barrier penetration, support its investigation in both in vitro and in vivo cancer research models, particularly for oncology and neuro-oncology applications.
Product Specifications
CAS Number
1616632-77-9
Product Name Alternative
ONC201; Dordaviprone
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Mitochondrial caseinolytic protease P activator / Anticancer agent
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml with warming)
Smiles
Cc1ccccc1CN1C2=NCCN2C2=C (CN (Cc3ccccc3) CC2) C1=O
Molecular Formula
C24H26N4O
Molecular Weight
386.49
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
7-Benzyl-4- (2-methylbenzyl) -1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5 (4H) -one
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