UNC2025
UNC-2025 (MRX-6343) is a potent, orally bioavailable small molecule inhibitor targeting MER and FLT3 kinases with IC50 values of 0.74 nM and 0.8 nM, respectively. It demonstrates approximately 20-fold selectivity over Axl and Tyro3. This inhibitor is a valuable research tool for studying oncology, particularly in leukemia and solid tumor models, both in vitro and in vivo.
Product Specifications
CAS Number
1429881-91-3
Product Name Alternative
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.48% (May vary between batches)
Solubility
H2O:Insoluble; Ethanol:8 mg/mL (16.78 mM) ; DMSO:35.71 mg/mL (74.92 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.39 mM)
Smiles
CCCCNc1ncc2c (cn ([C@H]3CC[C@H] (O) CC3) c2n1) -c1ccc (CN2CCN (C) CC2) cc1
Molecular Formula
C28H40N6O
Molecular Weight
476.66
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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