VER-155008
VER-155008 is a selective small molecule inhibitor of the Hsp70 family, demonstrating potent activity against HSP70, HSC70, and GRP78 with IC50 values of 0.5 μM, 2.6 μM, and 2.6 μM, respectively, and over 100-fold selectivity versus HSP90. It is a valuable research tool for studying protein folding, oncology, and neurodegenerative diseases in both cellular and biochemical assays.
Product Specifications
CAS Number
1134156-31-2
Product Name Alternative
Inhibit, Inhibitor, Heat shock proteins, HSC70, HSP, HSP70, GRP78, Autophagy, VER 155008, VER155008, VER-155008
Field of Research
Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
97.03% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.59 mM) ; DMSO:79.17 mg/mL (142.29 mM)
Smiles
Nc1ncnc2n ([C@@H]3O[C@H] (COCc4ccc (cc4) C#N) [C@@H] (O) [C@H]3O) c (NCc3ccc (Cl) c (Cl) c3) nc12
Molecular Formula
C25H23Cl2N7O4
Molecular Weight
556.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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