Selisistat S-enantiomer
The S-enantiomer of Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with an IC50 of 98 nM, exhibiting over 200-fold selectivity against SIRT2 and SIRT3. This compound is a valuable research tool for investigating SIRT1's role in aging, neurodegenerative diseases, and metabolic disorders in both cellular and animal models.
Product Specifications
CAS Number
848193-68-0
Product Name Alternative
Sirtuin, SIRT1, Selisistat S enantiomer, Selisistat Senantiomer, Selisistat S-enantiomer, inhibit, Inhibitor, EX-527, EX-527 (S-enantiomer), EX-527 S-enantiomer, EX 527, EX527, (S) -Selisistat
Field of Research
Epigenetics & Chromatin, Molecular Biology
Purity
99.69% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.04 mM) ; Ethanol:5 mg/mL (20.1 mM) ; DMSO:20 mg/mL (80.41 mM)
Smiles
NC (=O) [C@H]1CCCc2c1[nH]c1ccc (Cl) cc21
Molecular Formula
C13H13ClN2O
Molecular Weight
248.71
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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