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Selisistat S-enantiomer

The S-enantiomer of Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with an IC50 of 98 nM, exhibiting over 200-fold selectivity against SIRT2 and SIRT3. This compound is a valuable research tool for investigating SIRT1's role in aging, neurodegenerative diseases, and metabolic disorders in both cellular and animal models.

Product Specifications

CAS Number

848193-68-0

Product Name Alternative

Sirtuin, SIRT1, Selisistat S enantiomer, Selisistat Senantiomer, Selisistat S-enantiomer, inhibit, Inhibitor, EX-527, EX-527 (S-enantiomer), EX-527 S-enantiomer, EX 527, EX527, (S) -Selisistat

Field of Research

Epigenetics & Chromatin, Molecular Biology

Purity

99.69% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.04 mM) ; Ethanol:5 mg/mL (20.1 mM) ; DMSO:20 mg/mL (80.41 mM)

Smiles

NC (=O) [C@H]1CCCc2c1[nH]c1ccc (Cl) cc21

Molecular Formula

C13H13ClN2O

Molecular Weight

248.71

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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