CCT245737
CCT245737 is a potent and highly selective oral Chk1 inhibitor, exhibiting an IC50 of 1.3 nM with over 1,000-fold selectivity against CHK2 and CDK1. It is a valuable chemical probe for investigating DNA damage response pathways in cancer research, applicable in both cellular and in vivo model studies.
Product Specifications
CAS Number
1489389-18-5
Product Name Alternative
Checkpoint Kinase (Chk), CCT245737, CCT-245737, CCT 245737, Chk1, Inhibitor, inhibit, SRA 737, SRA737, SRA-737
Field of Research
Cell Biology
Purity
97.06% (May vary between batches)
Solubility
H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.27 mM) ; DMSO:48.33 mg/mL (127.41 mM) ; Ethanol:5 mg/mL (13.18 mM)
Smiles
FC (F) (F) c1cnc (Nc2cnc (cn2) C#N) cc1NC[C@H]1CNCCO1
Molecular Formula
C16H16F3N7O
Molecular Weight
379.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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