2-Bromo-4'-hydroxyacetophenone
2-Bromo-4'-hydroxyacetophenone (PTP Inhibitor I) is a cell-permeable, covalent inhibitor of SHP-1 and PTP1B (Ki ~42-43 μM) . Its inhibition of these phosphatases makes it a useful research tool for studying insulin signaling and immune cell regulation in the contexts of diabetes, inflammation, and cancer research.
Product Specifications
CAS Number
2491-38-5
Product Name Alternative
Inhibit, Inhibitor, alpha-Bromo-4-hydroxyacetophenone, a-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl Bromide, 4-Hydroxyphenacyl bromide, 2-Bromo-4'-hydroxyacetophenone, 2Bromo4'hydroxyacetophenone, 2 Bromo 4' hydroxyacetophenone, Phosphatase, SHP-1 Inhibitor II, PTP Inhibitor I, protein tyrosine phosphatase (PTP), α-Bromo-4-hydroxyacetophenone
Field of Research
Metabolism Research
Purity
98.64% (May vary between batches)
Solubility
H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.3 mM) ; Ethanol:20 mg/mL (93.01 mM) ; DMSO:60 mg/mL (279.02 mM)
Smiles
OC1=CC=C (C=C1) C (=O) CBr
Molecular Formula
C8H7BrO2
Molecular Weight
215.04
Storage Conditions
-20°C
Notes
For research use only.
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