PLX5622
PLX5622 is an orally bioavailable CSF1R inhibitor that selectively ablates microglia in rodent brains. It is extensively used in vivo to model microglia-related neuroinflammation, neurodegeneration (e.g., Alzheimer's and Parkinson's), brain injury, and neuroimmune interactions, facilitating both in vivo and in vitro mechanistic studies.
Product Specifications
CAS Number
1303420-67-8
Product Name Alternative
Inhibit, Inhibitor, microglial, pathology, orally, PLX5622, PLX-5622, PLX 5622, elimination, brain, CSF-1R, CSF-1 receptor, CSF1R, cFms, c-Fms, colony stimulating factor 1 receptor, preceding, penetrant
Field of Research
Immunology & Inflammation, Neuroscience
Purity
>98%
Bioactivity
CSF1R inhibitor (highly selective)
Form
Powder
Solubility
Soluble in DMSO (up to at least 25 mg/ml)
Smiles
COc1ncc (F) cc1CNc1ccc (Cc2c[nH]c3ncc (C) cc23) c (F) n1
Molecular Formula
C21H19F2N5O
Molecular Weight
395.4
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
6-Fluoro-N-[ (5-fluoro-2-methoxypyridin-3-yl) methyl]-5-[ (5-methyl-1H-pyrrolo[2,3-b]pyridine-3-yl) methyl]pyridine-2-amine
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