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AMG-47a

AMG-47a is a potent small molecule inhibitor of lymphocyte-specific protein tyrosine kinase (Lck), suppressing T-cell proliferation. It also acts as a selective degrader of the KRASG12V oncoprotein, as demonstrated in cellular studies, making it a valuable tool for oncology and immunology research.

Product Specifications

CAS Number

882663-88-9

Product Name Alternative

Janus kinase, JAK, immune, kinases, Inhibitor, inhibit, family, Lck, AMG 47a, AMG47a, AMG-47a, cell, cytoplamic, p38 MAPK, p38MAPK, receptor, signal, specific, Src, responses, VEGFR, Vascular endothelial growth factor receptor, transduction, tyrosine

Field of Research

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Purity

98.00% (May vary between batches)

Solubility

DMSO:34 mg/mL (63.48 mM)

Smiles

Cc1ccc (cc1-c1ccc2nc (NCCN3CCOCC3) ncc2c1) C (=O) Nc1cccc (c1) C (F) (F) F

Molecular Formula

C29H28F3N5O2

Molecular Weight

535.56

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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