TH-257
TH-257 is a potent and selective allosteric inhibitor of LIM kinase 1 and 2 (LIMK1/2), exhibiting IC50 values of 84 nM and 39 nM, respectively. This small molecule is a valuable research tool for investigating cytoskeletal dynamics in cellular models and has been utilized in studies exploring cancer cell metastasis and neuronal morphology.
Product Specifications
CAS Number
2244678-29-1
Product Name Alternative
TH257, TH-257, TH 257, Inhibitor, inhibit, LIMKs, LIMKinase, LIM Kinase, LIM Kinase (LIMK)
Field of Research
Cell Biology
Purity
98.00% (May vary between batches)
Solubility
DMSO:250 mg/mL (591.66 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.83 mM)
Smiles
CCCCN (Cc1ccccc1) C (=O) c1ccc (cc1) S (=O) (=O) Nc1ccccc1
Molecular Formula
C24H26N2O3S
Molecular Weight
422.54
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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