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Alflutinib mesylate

Alflutinib mesylate (AST2818 mesylate) is an irreversible EGFR tyrosine kinase inhibitor with high selectivity for mutant forms, including the T790M resistance mutation. It is utilized in preclinical oncology research, demonstrating activity in both cellular assays and animal models of non-small cell lung cancer.

Product Specifications

CAS Number

2130958-55-1

Product Name Alternative

Alflutinib Mesylate, Alflutinib mesylate, Alflutinib, AST 2818, AST 2818 Mesylate, AST2818, AST-2818, AST2818 Mesylate, AST2818 mesylate, AST-2818 Mesylate, cancer, NSCLC, inhibit, Inhibitor, HER1, EGFR, Epidermal growth factor receptor, ErbB-1, Furmonertinib, esistant mutation, T790M

Field of Research

Cardiovascular Research, Signal Transduction

Purity

97.94% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (1.5 mM) ; DMSO:55 mg/mL (82.74 mM)

Smiles

CS (O) (=O) =O.CN (C) CCN (C) c1nc (OCC (F) (F) F) c (Nc2nccc (n2) -c2cn (C) c3ccccc23) cc1NC (=O) C=C

Molecular Formula

C29H35F3N8O5S

Molecular Weight

664.70

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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