Firsocostat
Firsocostat (GS-0976) is a potent small molecule inhibitor of acetyl-CoA carboxylase (ACC) that disrupts dimerization, with IC50 values of 2.1 nM for ACC1 and 6.1 nM for ACC2. It is a valuable research tool for investigating lipid metabolism in non-alcoholic steatohepatitis (NASH) and metabolic disorders, with utility in both in vitro and preclinical in vivo models.
Product Specifications
CAS Number
1434635-54-7
Product Name Alternative
ND-630; NDI-010976; GS-0976
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Allosteric acetyl-CoA carboxylase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to at least 25 mg/ml)
Smiles
COc1ccccc1[C@H] (Cn1c2sc (c (C) c2c (=O) n (c1=O) C (C) (C) C (O) =O) -c1ncco1) OC1CCOCC1
Molecular Formula
C28H31N3O8S
Molecular Weight
569.6
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-[1-[ (2R) -2- (2-Methoxyphenyl) -2-9oxan-4-yloxy) ethyl]-5-methyl-6- (1,3-oxazol-2-yl) -2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid
Available Sizes
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